Gary D Lopaschuk Selected Research

Fatty Acids (Saturated Fatty Acids)

11/2021	The Contribution of Cardiac Fatty Acid Oxidation to Diabetic Cardiomyopathy Severity.
1/2021	Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma.
1/2021	Cardiac Energy Metabolism in Heart Failure.
12/2020	Ketone metabolism in the failing heart.
6/2019	Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.
1/2019	Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity.
1/2019	Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency.
11/2018	Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart.
1/2018	Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.
1/2018	Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism.

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Gary D Lopaschuk Research Topics

Disease

41	Heart Failure 02/2022 - 07/2002
40	Insulin Resistance 02/2022 - 05/2002
31	Ischemia 11/2015 - 02/2002
26	Obesity 01/2022 - 01/2007
20	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 09/2002
17	Hypertrophy 01/2019 - 01/2002
15	Cardiomegaly (Heart Hypertrophy) 01/2019 - 04/2002
9	Heart Diseases (Heart Disease) 01/2018 - 01/2007
6	Type 2 Diabetes Mellitus (MODY) 02/2022 - 01/2013
6	Fibrosis (Cirrhosis) 01/2022 - 09/2009
6	Inflammation (Inflammations) 01/2022 - 03/2014
6	Reperfusion Injury 11/2021 - 06/2004
6	Diabetic Cardiomyopathies 11/2021 - 01/2002
6	Cardiomyopathies (Cardiomyopathy) 01/2021 - 01/2002
6	Myocardial Infarction 06/2019 - 09/2002
6	Hypoxia (Hypoxemia) 01/2016 - 01/2006
6	AIDS-Related Complex (ARC) 08/2013 - 10/2007
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 08/2007
4	Hypertension (High Blood Pressure) 01/2021 - 05/2009
4	Infarction (Infarctions) 01/2016 - 10/2010
4	Body Weight (Weight, Body) 10/2014 - 10/2007
3	Hyperglycemia 01/2022 - 09/2005
3	Left Ventricular Dysfunction 01/2014 - 12/2008
3	Glucose Intolerance 03/2013 - 01/2008
3	Pulmonary Hypertension 03/2013 - 01/2002
2	Weight Loss (Weight Reduction) 01/2022 - 01/2019
2	Neoplasms (Cancer) 01/2021 - 01/2007
2	Right Ventricular Hypertrophy 03/2013 - 01/2010
2	Atherosclerosis 06/2012 - 02/2005
2	Ventricular Dysfunction 04/2011 - 01/2002

Drug/Important Bio-Agent (IBA)

76	Fatty Acids (Saturated Fatty Acids)IBA 11/2021 - 01/2002
65	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 01/2002
24	Insulin (Novolin)FDA Link 01/2019 - 05/2002
22	EnzymesIBA 01/2021 - 05/2002
18	Malonyl Coenzyme A (Malonyl CoA)IBA 01/2021 - 09/2002
14	LipidsIBA 01/2021 - 03/2006
13	malonyl-CoA decarboxylaseIBA 01/2021 - 12/2005
12	Adenosine Triphosphate (ATP)IBA 11/2021 - 01/2005
12	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2002
8	Oxygen (Dioxygen)IBA 01/2017 - 01/2006
8	AMP-Activated Protein KinasesIBA 06/2013 - 06/2004
7	CarbohydratesIBA 01/2022 - 03/2004
7	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 12/2005
7	Pyruvic Acid (Pyruvate)IBA 01/2019 - 12/2005
7	Angiotensin IIIBA 04/2014 - 09/2006
6	Triglycerides (Triacylglycerol)IBA 06/2014 - 05/2002
6	Lactic Acid (Lactate)FDA LinkGeneric 09/2013 - 05/2004
6	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 04/2013 - 01/2007
6	PalmitatesIBA 01/2013 - 03/2004
6	LeptinIBA 11/2011 - 03/2006
5	KetonesIBA 01/2022 - 03/2004
5	CeramidesIBA 06/2015 - 10/2010
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 12/2008
4	Branched-Chain Amino AcidsIBA 11/2021 - 11/2018
4	Trimetazidine (Vastarel)IBA 01/2016 - 08/2003
4	AcidsIBA 01/2016 - 05/2002
4	GlycogenIBA 10/2014 - 04/2002
4	Acetyl-CoA CarboxylaseIBA 08/2014 - 05/2002
4	Carnitine (L-Carnitine)FDA LinkGeneric 12/2013 - 04/2002
3	CalciumIBA 01/2022 - 03/2004
3	Angiotensin-Converting Enzyme 2IBA 01/2020 - 03/2014
3	salicylhydroxamic acid (SHAM)IBA 01/2019 - 09/2008
3	Lysine (L-Lysine)FDA Link 12/2016 - 12/2007
3	DiglyceridesIBA 01/2016 - 10/2010
3	AdiponectinIBA 01/2016 - 08/2007
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2015 - 01/2002
3	Protein Kinases (Protein Kinase)IBA 06/2015 - 05/2003
3	Serine (L-Serine)FDA Link 06/2015 - 10/2010
3	Protons (Proton)IBA 01/2014 - 05/2003
3	Appetite Depressants (Anorectics)IBA 08/2013 - 06/2011
3	Protein Isoforms (Isoforms)IBA 08/2012 - 07/2010
3	Adenosine Monophosphate (AMP)IBA 05/2012 - 01/2005
3	Nonesterified Fatty Acids (NEFA)IBA 12/2011 - 10/2004
3	Krebs-Henseleit solutionIBA 07/2009 - 03/2004
2	SodiumIBA 02/2022 - 12/2020
2	SymportersIBA 02/2022 - 12/2020
2	Sodium-Hydrogen ExchangersIBA 06/2020 - 01/2011
2	empagliflozinIBA 01/2020 - 10/2018
2	Glucagon (Glukagon)FDA Link 01/2019 - 01/2013
2	ResveratrolIBA 01/2019 - 10/2013
2	Glucagon Receptors (Glucagon Receptor)IBA 01/2019 - 01/2013
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019 - 01/2011
2	AdipokinesIBA 01/2017 - 08/2007
2	AngiotensinsIBA 01/2016 - 07/2012
2	CalreticulinIBA 01/2016 - 01/2013
2	NAD (NADH)IBA 11/2015 - 08/2012
2	Therapeutic UsesIBA 04/2015 - 03/2014
2	Adenine NucleotidesIBA 10/2014 - 07/2009
2	Coenzyme A (CoA)IBA 08/2014 - 08/2010
2	Acetyl Coenzyme A (Acetyl-CoA)IBA 08/2014 - 07/2009
2	Acyl Coenzyme A (Acyl CoA)IBA 06/2014 - 01/2011
2	angiotensin I (1-7)IBA 04/2014 - 03/2014
2	TransferasesIBA 04/2013 - 01/2012
2	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2013 - 01/2008
2	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 07/2012 - 03/2007

Therapy/Procedure

19	Therapeutics 01/2022 - 04/2007
3	Ketogenic Diet 01/2022 - 12/2020
2	Fat-Restricted Diet (Diet, Fat Restricted) 01/2022 - 01/2021
2	Ligation 06/2019 - 05/2012
2	Glycemic Control 01/2019 - 06/2014